{"id":53,"date":"2019-09-02T09:43:32","date_gmt":"2019-09-02T09:43:32","guid":{"rendered":"https:\/\/xspraypharma.com\/?page_id=53"},"modified":"2025-09-09T12:25:17","modified_gmt":"2025-09-09T12:25:17","slug":"teknologi","status":"publish","type":"page","link":"https:\/\/xspraypharma.com\/sv\/teknologi\/","title":{"rendered":"Teknologi"},"content":{"rendered":"<section class=\"block content-block\">\n\t\t\t\t\t\t<div class=\"container-fluid container-small editor_content\">\n\t\t\t\t<h2>En unik teknologi m\u00f6jligg\u00f6r f\u00f6rb\u00e4ttrad cancerbehandling<\/h2>\n<p>Proteinkinash\u00e4mmare (PKI, Protein Kinase Inhibitors) har visat sig h\u00e4mma cancerns tillv\u00e4xt, vilket medf\u00f6r f\u00f6rl\u00e4ngd \u00f6verlevnad och att patienten oftast behandlas under flera \u00e5r, i vissa fall under hela livet. Majoriteten av de marknadsf\u00f6rda PKI:erna inneh\u00e5ller kristallina former av de aktiva l\u00e4kemedelssubstanserna.<\/p>\n<p>Ett allm\u00e4nt k\u00e4nt problem med kristallina former av PKI:er \u00e4r att de \u00e4r sv\u00e5rl\u00f6sliga och deras l\u00f6sligheten varierar beroende av mags\u00e4ckens pH-v\u00e4rde (surhetsgrad), vilket kan resultera i ett mycket oj\u00e4mnt upptag av l\u00e4kemedlet i kroppen, s\u00e5 kallad h\u00f6g variabilitet, speciellt vid samtidig behandling med pH-h\u00f6jande l\u00e4kemedel, t.ex. omeprazol, eller vid intag av mat. Variabiliteten \u00f6kar risken f\u00f6r att den terapeutiska effekten uteblir, vid ett f\u00f6r l\u00e5gt upptag av l\u00e4kemedlet kan cancern f\u00e5 fart igen, och vid ett f\u00f6r h\u00f6gt upptag \u00f6kar risken f\u00f6r sidoeffekter.<\/p>\n\t\t\t<\/div>\n\t\t\t<\/section>\n\n\n\n<section class=\"block image-text image_left\">\n\t<div class=\"container-fluid\">\n\t\t<div class=\"block-row\">\n\t\t\t<figure class=\"image-col\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"488\" height=\"394\" src=\"https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-488x394.png\" class=\"attachment-image-text size-image-text\" alt=\"\" srcset=\"https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-488x394.png 488w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-300x242.png 300w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-768x620.png 768w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-1024x827.png 1024w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-780x630.png 780w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-320x258.png 320w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-238x192.png 238w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-220x178.png 220w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-171x138.png 171w, https:\/\/xspraypharma.com\/wp-content\/uploads\/2019\/11\/nibs-e1638182223999.png 800w\" sizes=\"auto, (max-width: 488px) 100vw, 488px\" \/>\t\t\t<\/figure>\n\t\t\t<article class=\"text-col\">\n\t\t\t\t\t\t\t\t\t<div class=\"editor_content\">\n\t\t\t\t\t\t<p>Xspray Pharmas teknologi \u00e4r synnerligen l\u00e4mpad f\u00f6r att \u00f6vervinna m\u00e5nga av de brister som PKI-substanser generellt sett har. Bolaget producerar stabila amorfa PKI:er som \u00e4r l\u00e4ttl\u00f6sliga och d\u00e4r upptaget i kroppen \u00e4r pH-oberoende, vilket betyder att upptaget av l\u00e4kemedlet i kroppen blir j\u00e4mnt, \u00e4ven vid intag av mat eller pH-h\u00f6jande l\u00e4kemedel. Teknologin g\u00f6r det dessutom m\u00f6jligt att justera hur mycket l\u00e4kemedel som ska tas upp i kroppen.<\/p>\n<p>Xspray Pharmas unika teknologi \u00e4r applicerbar p\u00e5 en majoritet av PKI l\u00e4kemedel. Framtagandet av bolagets nya produktkandidater sker p\u00e5 samma s\u00e4tt som f\u00f6r bolagets f\u00f6rsta produkt Dasynoc (dasatinib). Teknologin \u00e4r reproducerbar vilket effektiviserar och f\u00f6rkortar utvecklingstiden f\u00f6r kommande produkter i bolagets pipeline.<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/article>\n\t\t<\/div>\n\t<\/div>\n<\/section>\n\n\n\n<section class=\"block content-block\">\n\t\t\t\t\t\t<div class=\"container-fluid container-small editor_content\">\n\t\t\t\t<p>Den viktigaste aspekten vid utvecklingen av en amorf produkt \u00e4r dess stabilitet under lagring. Amorfa produkter tenderar att \u00e5terg\u00e5 till ett mer stabilt kristallint tillst\u00e5nd under lagring vilket kan leda till att l\u00f6sligheten och d\u00e4rmed absorptionen blir l\u00e4gre.<\/p>\n<p>Xspray Pharmas produkter har visat sig f\u00f6rbli helt amorfa under l\u00e5ngtidslagring. Bolagets dasatinib tabletter har unders\u00f6kts med ett ytterst k\u00e4nsligt instrument som anv\u00e4nds f\u00f6r att detektera kristallint material. I analysen fanns inga sp\u00e5r av kristallint material, vilket bekr\u00e4ftar tidigare studier som har visat att bolagets HyNap-material f\u00f6rblir amorft och utan sp\u00e5r av kristallinitet i mer \u00e4n tre \u00e5r i rumstemperatur. Bolagets HyNap-material kan d\u00e4rf\u00f6r bli produkter med l\u00e5ng h\u00e5llbarhet vilket \u00e4r avg\u00f6rande f\u00f6r bolagets aff\u00e4rsmodell.<\/p>\n<p>Teknologin baserar sig p\u00e5 superkritisk v\u00e4tskeextraktion. Molekyler i ett superkritiskt tillst\u00e5nd kan r\u00f6ra sig snabbt, som i en gas, samtidigt som f\u00f6rm\u00e5gan att l\u00f6sa \u00e4mnen \u00e4r god, som i en v\u00e4tska. Den superkritiska v\u00e4tskan anv\u00e4nds som ett antil\u00f6snings medel f\u00f6r kontrollerad partikelutf\u00e4llning av API (Active Pharmaceutical Ingredient) med eller utan tillsats av hj\u00e4lp\u00e4mnen.<\/p>\n<p>&nbsp;<\/p>\n\t\t\t<\/div>\n\t\t\t<\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-53","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Teknologi - Xspray<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xspraypharma.com\/sv\/teknologi\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Teknologi - 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